One Week of Continuous Anesthesia by Propofol (2,6-Diisopropylphenol) Does Not Cause Neurobehavioral Changes after Recovery in the Mexican Axolotl Salamander

The Mexican axolotl salamander is an important model species in regenerative medical research and experiments involving this often require anesthesia which usually limited to the duration of surgical procedure or other interventions, lasting no more than a few hours. This study aimed examine potential for increasing by continued propofol infusion week. Neurobehavioral changes response prolonged were evaluated after two seven days recovery assessing resultant tactile nociceptive stimulation tracking activity levels post-anesthesia. No indications neurotoxicity found, but significant reversible swelling was observed. concern should be addressed before attempting extend beyond one week future experiments. In summary, our demonstrated long-term with neurotoxicity.